AAV Data Hub

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Image Injection Site Expression Site Species / Subject Serotype Promoter Tool Type Addgene Catalog Item

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Brain parenchyma
Dorsal anterior cingulate cortex/medial secondary motor cortex of mouse. Neuronal cell class
Mouse AAV1 Syn Recombinase pENN.AAV.hSyn.Cre.WPRE.hGH
(#105553-AAV1)

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Cerebrospinal fluid (CSF): Intracerebroventricular (ICV)
Neurons in forebrain- cortex, hippocampus, some mid brain
Mouse AAV1 Syn Biosensor pAAV-hSyn1-mRuby2-GSG-P2A-GCaMP6f-WPRE-pA
(#50943-AAV1)

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Cerebrospinal fluid (CSF): Intracerebroventricular (ICV)
Neurons of the forebrain, cortex, hippocampus some midbrain as well
Mouse AAV1 Syn Biosensor pAAV.hSyn1.Twitch2B.WPRE.SV40
(#100040-AAV1)

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Incubated organotypic slices in virus at the time of slicing
Hippocampal neurons
Mouse AAV9 Syn Biosensor pGP-AAV-syn-jGCaMP7f-WPRE
(#104488-AAV9)

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Brain parenchyma
Expression was local to the barrel cortex. Assumed excitatory cells, but we did not attempt to verify co-localization between the virus expression and CamKII as these experiments were largely used for testing
Mouse AAV9 CaMKIIa Biosensor AAV.CamKII.GCaMP6s.WPRE.SV40
(#107790-AAV9)

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Intravenous (retro-orbital or tail vein)
Widespread infection throughout the brain. In both excitatory pyramidal neurons, as well as glia. Density was fairly uniform across cortical regions
Mouse PHP.eB CAG Control pAAV-CAG-tdTomato (codon diversified)
(#59462-PHPeB)

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Intravenous (retro-orbital or tail vein)
In the olfactory epithelium, I observed very sparse expression in the sensory neurons and stronger expression in sustentacular cells
Mouse PHP.S CAG Control pAAV-CAG-tdTomato (codon diversified)
(#59462-PHP.S)

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Brain parenchyma
Injection site: dorsal anterior cingulate cortex/medial secondary motor cortex of mouse
Mouse AAV1 CaMKIIa Biosensor pENN.AAV.CamKII.GCaMP6f.WPRE.SV40
(#100834-AAV1)

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Intravenous (retro-orbital or tail vein)
Cortical and hippocampal neurons
Mouse AAV9 Syn Optogenetics pAAV-Syn-ChrimsonR-tdT
(#59171-AAV9)

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Brain parenchyma
Cholecystokinin (cck) cells in the hypothalamus of a cck-cre mouse line
Mouse AAV9 CAG Control AAV-FLEX-Arch-GFP
(#22222-AAV9)

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Brain parenchyma
Area X, HVC
Zebra finch AAV1 CaMKIIa Optogenetics pAAV-CamKII-ArchT-GFP (PV2527)
(#99039-AAV1)

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Brain parenchyma
Cholecystokinin (cck) cells in the hypothalamus of a cck-cre mouse line
Mouse AAV9 EF1a Optogenetics pAAV-EF1a-double floxed-hChR2(H134R)-EYFP-WPRE-HGHpA
(#20298-AAV9)

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Brain parenchyma
The perforant path fiber in dentate gyrus
Mouse AAV2 Syn Chemogenetics pAAV-hSyn-hM4D(Gi)-mCherry
(#50475-AAV2)

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Dorsal hpc
HPC astrocytes
Rat AAV5 GFAP Chemogenetics pAAV-GFAP-hM4D(Gi)-mCherry
(#50479-AAV5)

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Brain parenchyma
CA1 & CA3=pyramidal cells. Dentate gyrus= granual cells. Entorhinal cortex= pyramidal cells
Mouse AAV8 CaMKIIa Chemogenetics pAAV-CaMKIIa-hM4D(Gi)-mCherry
(#50477-AAV8)

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Brain parenchyma
Cholecystokinin (cck) cells in the hypothalamus of a cck-cre mouse line
Mouse AAV8 Syn Chemogenetics pAAV-hSyn-DIO-hM3D(Gq)-mCherry
(#44361-AAV8)

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Brain parenchyma
Viral expression was well-contained within the medial septum. Terminal expression was seen in common terminating regions and particularly widespread in the hippocampus
Rat AAV2 Syn Control pAAV-hSyn-EGFP
(#50465-AAV2)

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Brain parenchyma
Good expression on cell bodies within the medial septum as well as terminals in terminating regions. Cell type unknown
Rat AAV2 Syn Chemogenetics pAAV-hSyn-hM3D(Gq)-mCherry
(#50474-AAV2)

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Brain parenchyma
Cholecystokinin (cck) cells in the hypothalamus of a cck-cre mouse line
Mouse AAV9 EF1a Control pAAV-Ef1a-DIO EYFP
(#27056-AAV9)

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Brain parenchyma
Targeted region (SCN) and part of PVN
Mouse AAV8 Syn Chemogenetics pAAV-hSyn-DIO-hM3D(Gq)-mCherry
(#44361-AAV8)

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Brain parenchyma
This virus is hard to get into SCN. You can see it in the attached image. AAV1 might work better than this (AAV8)
Mouse AAV8 Syn Control pAAV-hSyn-DIO-mCherry
(#50459-AAV8)

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Brain parenchyma
Only in the targeted region. Very good expression
Mouse AAV1 Syn Biosensor pAAV.Syn.Flex.GCaMP6f.WPRE.SV40
(#100833-AAV1)

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Brain parenchyma
Anterior insular cortex (with contamination in somatosensory cortex), without cell-type specificity
Mouse AAV1 Syn Biosensor pAAV.Syn.GCaMP6f.WPRE.SV40
(#100837-AAV1)

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Brain parenchyma
Non-specific neurons in nucleus solitary tract
Mouse AAV1 Syn Biosensor pAAV.Syn.GCaMP6f.WPRE.SV40
(#100837-AAV1)

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Brain parenchyma
Ventral hippocampal CA1 pyramidal neurons projecting to the mPFC
Mouse AAV5 Syn Control pAAV-hSyn-DIO-mCherry
(#50459-AAV5)

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Brain parenchyma
Ventral CA1 neurons, presumably excitatory
Mouse AAV5 Syn Chemogenetics pAAV-hSyn-DIO-hM4D(Gi)-mCherry
(#44362-AAV5)

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Brain parenchyma
Lateral habenula, neurons
Mouse AAV8 Syn Chemogenetics pAAV-hSyn-DIO-hM3D(Gq)-mCherry
(#44361-AAV8)

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Brain parenchyma
Robust and widespread expression at injection site in parabrachial nucleus. A moderate number of target cells (projection neurons in lamina I of the spinal cord) also expressed genetic cargo
Mouse AAV Retrograde Syn Recombinase AAV pmSyn1-EBFP-Cre
(#51507-AAVrg)

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Brain parenchyma
Of all neuronal types that could potentially have expressed the virus, only pyramidal cells in the auditory cortex were detectable by observing direct fluorescence
Guinea pig AAV Retrograde CAG Control pAAV-CAG-GFP
(#37825-AAVrg)

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Retina
Virus were injected into Opn4-Cre mice. Melanopsin-expressing intrinsically photosensitive retinal ganglion cells ended up expressing hM3D from viral infection
Mouse AAV2 Syn Chemogenetics pAAV-hSyn-DIO-hM3D(Gq)-mCherry
(#44361-AAV2)

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Brain parenchyma
VTA, dopamine neurons
Rat AAV2 Syn Chemogenetics pAAV-hSyn-DIO-hM3D(Gq)-mCherry
(#44361-AAV2)

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Brain parenchyma
Ventral Pallidum, GABA neurons
Rat AAV2 Syn Chemogenetics pAAV-hSyn-DIO-hM4D(Gi)-mCherry
(#44362-AAV2)

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Brain parenchyma
Cholinergic neuron cell bodies and axons originating from nucleus basalis
Rat AAV8 Syn Chemogenetics pAAV-hSyn-DIO-hM4D(Gi)-mCherry
(#44362-AAV8)

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Brain parenchyma
Ventral Pallidum, GABA neurons
Rat AAV2 Syn Control pAAV-hSyn-DIO-mCherry
(#50459-AAV2)

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Brain parenchyma
Cre positive (cck-expressing) cells in the hypothalamus
Mouse AAV8 Syn Control pAAV-hSyn-DIO-mCherry
(#50459-AAV8)

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Trigeminal gangion
Trigeminal ganglion and cranial meninges
Mouse AAV5 CAG Biosensor pAAV.CAG.GCaMP6s.WPRE.SV40
(#100844-AAV5)

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Brain parenchyma
Insular cortex and Fezf2 neurons in layer 5/6
Mouse AAV1 Syn Biosensor pAAV.Syn.Flex.GCaMP6f.WPRE.SV40
(#100833-AAV1)

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Brain parenchyma
Cerebellum, Bergmann glia
Mouse AAV5 GFAP Biosensor pZac2.1 gfaABC1D-cyto-GCaMP6f
(#52925-AAV5)

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Brain parenchyma
AAVrg-cre was visualized in VP cells expressing synapsin. DIO-hM4D(Gi) was visualized in cells of NAc that project to VP
Rat AAV Retrograde Syn Recombinase AAV pmSyn1-EBFP-Cre
(#51507-AAVrg)

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Brain parenchyma
L5 pyramidal cells
Mouse AAV9 CAG Biosensor pAAV.CAG.Flex.GCaMP6s.WPRE.SV40
(#100842-AAV9)

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Brain parenchyma
Injection site (FLEX virus) specific
Mouse AAV Retrograde Syn Recombinase AAV pmSyn1-EBFP-Cre
(#51507-AAVrg)

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Brain parenchyma
VTA, dopamine neurons
Rat AAV8 Syn Chemogenetics pAAV-hSyn-dF-HA-KORD-IRES-mCitrine
(#65417-AAV8)

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Brain parenchyma
Expression was found throughout the brain in cell bodies of common afferents to the medial septum. These included the ventral tegmental area, lateral septum, and medial and orbital prefrontal cortices. The expression was not cell-type specific as far as we could tell
Rat AAV Retrograde Syn Chemogenetics pAAV-hSyn-hM3D(Gq)-mCherry
(#50474-AAVrg)

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Brain parenchyma
Layer 5 pyramidal neurons in S1 barrel field. This was an RPP4-cre mouse, which sparsely labels layer 5 pyramidal cells
Mouse AAV1 Syn Biosensor pAAV.hSyn.Flex.iGluSnFr.WPRE.SV40
(#98931-AAV1)

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Brain parenchyma
Ventral hippocampal CA1 cells
Mouse AAV Retrograde Syn Biosensor AAV-hSyn1-GCaMP6s-P2A-nls-dTomato
(#51085-AAVrg)

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Brain parenchyma
Primary motor cortex
Mouse AAV5 EF1a Optogenetics pAAV-EF1a-double floxed-hChR2(H134R)-EYFP-WPRE-HGHpA
(#20298-AAV5)

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Brain parenchyma
Prelimbic neurons
Mouse AAV5 Syn Biosensor pAAV-hSyn-dLight1.2
(#111068-AAV5)

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Brain parenchyma
Direct pathway medium spiny neurons of the nucleus accumbens
Rat AAV Retrograde Syn Biosensor AAV-hSyn1-GCaMP6s-P2A-nls-dTomato
(#51084-AAVrg)

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Brain parenchyma
Strong expression of neuronal cell bodies in most areas known to project to putamen (various areas of cortex, amygdala, subthalamic nucleus, Gpe); with two major exceptions: intralaminar nuclei of the thalamus and
Rhesus macaque AAV Retrograde Syn Optogenetics pAAV-hsyn-Jaws-KGC-GFP-ER2
(#65014-AAVrg)

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Brain parenchyma
Putative CaMKII+ cells in nucleus reuniens (RE) were labeled
Mouse AAV5 CaMKIIa Chemogenetics pAAV-CaMKIIa-hM4D(Gi)-mCherry
(#50477-AAV5)

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Cerebrospinal fluid (CSF): Intracerebroventricular (ICV)
Imaging was performed on hippocampal organotypic slice cultures. Interneurons expressed the construct
Mouse AAV9 CAG Control AAV pCAG-FLEX-tdTomato-WPRE
(#51503-AAV9)

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Brain parenchyma
Ventral hippocampus
Mouse AAV Retrograde Syn Biosensor AAV-hSyn1-GCaMP6s-P2A-nls-dTomato
(#51084-AAVrg)

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Infected cells in vitro
Neurons
Human (ex: human brain slices) AAV1 Syn Biosensor AAV-hSyn1-GCaMP6s-P2A-nls-dTomato
(#51084-AAV1)

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Brain parenchyma
Mouse AAV1 Syn Biosensor pAAV_hSyn1-SIO-stGtACR2-FusionRed
(#105677-AAV1)

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Brain parenchyma
CA1 in dorsal hippocampus / pyramidal neurons
Mouse AAV8 CaMKIIa Control pAAV-CaMKIIa-EGFP
(#50469-AAV8)

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Brain parenchyma
CA1, subiculum, dentate gyrus
Mouse AAV1 CaMKIIa Optogenetics pAAV-CaMKIIa-eNpHR 3.0-EYFP
(#26971-AAV1)

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Brain parenchyma
Ventral hippocampus and nearby cortex
Mouse AAV1 CaMKIIa Optogenetics pAAV-CaMKIIa-hChR2(H134R)-EYFP
(#26969-AAV1)

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Brain parenchyma
Anterior Insular Cortex - CamkII positive neurons
Mouse AAV9 CaMKIIa Optogenetics pAAV-CaMKIIa-hChR2(H134R)-EYFP
(#26969-AAV9)

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Brain parenchyma
Principal neurons in auditory cortex (axons mostly)
Mouse AAV9 CaMKIIa Optogenetics pAAV-CaMKIIa-hChR2(H134R)-mCherry
(#26975-AAV9)

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Brain parenchyma
GnRH neurons in the median preoptic nucleus (MnPO)
Mouse AAV Retrograde EF1a Optogenetics pAAV-EF1a-double floxed-hChR2(H134R)-EYFP-WPRE-HGHpA
(#20298-AAVrg)

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Zona incerta
ZI PV cells
Mouse AAV9 EF1a Optogenetics pAAV-EF1a-double floxed-hChR2(H134R)-EYFP-WPRE-HGHpA
(#20298-AAV9)

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Brain parenchyma
Injections were in L4 level of spinal cord, visualized retrogradely labeled cells from RVM in the KOR-cre mouse line generated within our lab
Mouse AAV Retrograde Syn Chemogenetics pAAV-hSyn-DIO-hM3D(Gq)-mCherry
(#44361-AAVrg)

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Brain parenchyma
Ventral dentate gyrus, putative excitatory neurons
Mouse AAV8 Syn Chemogenetics pAAV-hSyn-DIO-hM3D(Gq)-mCherry
(#44361-AAV8)

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Brain parenchyma
CRH neuron in the bed nucleus of the stria terminalis
Mouse AAV9 Syn Chemogenetics pAAV-hSyn-DIO-hM4D(Gi)-mCherry
(#44362-AAV9)

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Brain parenchyma
Within lateral parabrachial nucleus
Mouse AAV2 Syn Control pAAV-hSyn-DIO-mCherry
(#50459-AAV2)

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Brain parenchyma
Insular cortex neurons projecting to thalamic/habenula area
Rat AAV8 Syn Control pAAV-hSyn-DIO-mCherry
(#50459-AAV8)

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Brain parenchyma
Dorsal anterior cingulate cortex/medial secondary motor cortex of mouse
Mouse AAV5 Syn Biosensor pAAV-hSyn-dLight1.2
(#111068-AAV5)

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Brain parenchyma
Pyramidal tract neurons in motor, sensory, cingulate, and prelimbic cortices. Some expression in ventroorbital cortex and infralimbic cortex as well
Rat AAV Retrograde Syn Chemogenetics pAAV-hSyn-hM4D(Gi)-mCherry
(#50475-AAVrg)

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Directly into brain tissue
Dopaminergic/TH+ cells, as expected
Rat AAV5 Syn Optogenetics pAAV-Syn-FLEX-rc[ChrimsonR-tdTomato]
(#62723-AAV5)

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Brain parenchyma
Nucleus accumbens medial shell with minor spillover to ventral lateral septum (no cell specificity)
Mouse AAV1 Syn Biosensor pAAV.hSynapsin.SF-iGluSnFR.A184S
(#106174-AAV1)

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Brain parenchyma
Parvalbumin-expressing GABAergic neurons
Mouse AAV1 Syn Biosensor pAAV.Syn.Flex.NES-jRGECO1a.WPRE.SV40
(#100853-AAV1)

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Brain parenchyma
GCaMP PT expression, jRGECO IT expression
Rat AAV Retrograde Syn Biosensor pAAV.Syn.NES-jRGECO1a.WPRE.SV40
(#100854-AAVrg)

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Brain parenchyma
Dorsal anterior cingulate cortex/medial secondary motor cortex of mouse
Mouse AAV1 Syn Biosensor pAAV.Syn.NES-jRGECO1a.WPRE.SV40
(#100854-AAV1)

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Brain parenchyma
Ventral CA1 neurons with projections to the PrL
Mouse AAV Retrograde Syn Recombinase AAV pmSyn1-EBFP-Cre
(#51507-AAVrg)

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Brain parenchyma
Mouse AAV Retrograde CAG Control pAAV-CAG-tdTomato (codon diversified)
(#59462-AAVrg)

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Brain parenchyma
Expression was largely localized to the prelimbic cortex, with some expression also observed in the medial orbitofrontal cortex and infralimbic cortex. Expression was limited to neurons expressing parvalbumin
Mouse AAV5 Syn Biosensor pAAV.Syn.Flex.GCaMP6s.WPRE.SV40
(#100845-AAV5)

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Cerebrospinal fluid (CSF): Intracerebroventricular (ICV)
PT neurons in the motor cortex
Mouse AAV Retrograde CAG Control pAAV-CAG-tdTomato (codon diversified)
(#59462-AAVrg)

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Cerebrospinal fluid (CSF): Intracerebroventricular (ICV)
IT neurons in the contralateral motor cortex
Mouse AAV Retrograde CAG Control pAAV-CAG-tdTomato (codon diversified)
(#59462-AAVrg)

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Brain parenchyma
Cortical astrocytes
Mouse AAV5 GFAP Chemogenetics pAAV-GFAP-hM3D(Gq)-mCherry
(#50478-AAV5)

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Brain parenchyma
Ventral CA1 pyramidal neurons
Mouse AAV Retrograde Syn Recombinase pENN.AAV.hSyn.Cre.WPRE.hGH
(#105553-AAVrg)

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Brain parenchyma
Neurons in the Lateral Habenula (injection site) and retrogradely labeled brain areas that project to the Lateral Habenula (eg, Lateral Hypothalamus)
Rat AAV Retrograde Syn Recombinase pENN.AAV.hSyn.Cre.WPRE.hGH
(#105553-AAVrg)

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Brain parenchyma
The gfaABC1D-lck-GCaMP6f (AAV5) virus works really well. It spreads nicely after the injection and shows membrane labelling only in astrocytes. We have never detected expression in other cell types
Mouse AAV5 GFAP Biosensor pZac2.1 gfaABC1D-lck-GCaMP6f
(#52924-AAV5)

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Brain parenchyma
Layer 2/3 neurons, and some Layer 4 cells
Mouse AAV9 Syn Biosensor pAAV.Syn.GCaMP6f.WPRE.SV40
(#100837-AAV9)

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Brain parenchyma
No successful expression
Rat AAV1 EF1a Biosensor AAV-EF1a-DIO-GCaMP6s-P2A-nls-dTomato
(#51082-AAV1)

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Brain parenchyma
Putative CaMKII+ cells in the pyramidal layer of the CA1 subregion
Mouse AAV9 CaMKIIa Optogenetics pAAV-CaMKIIa-hChR2(H134R)-EYFP
(#26969-AAV9)

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Brain parenchyma
Indirect pathway medium spiny neurons of the nucleus accumbens
Rat AAV Retrograde Syn Biosensor pGP-AAV-syn-jGCaMP7s-WPRE
(#104487-AAVrg)

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Brain parenchyma
CA1 region of dorsal hippocampus / pyramidal neurons
Mouse AAV8 CaMKIIa Chemogenetics pAAV-CaMKIIa-hM4D(Gi)-mCherry
(#50477-AAV8)

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Brain parenchyma
Noradrenergic cells of the locus coeruleus
Rat AAV5 EF1a Optogenetics pAAV-Ef1a-DIO ChETA-EYFP
(#26968-AAV5)

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Brain parenchyma
Prelimbic cortex, Prelimbic neurons that project to the dorsal raphe nucleus
Rat AAV8 Syn Chemogenetics pAAV-hSyn-DIO-hM4D(Gi)-mCherry
(#44362-AAV8)

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Brain parenchyma
Oxytocinergic neurons in paraventricular hypothalamic nucleus
Mouse AAV9 CAG Biosensor pAAV.CAG.Flex.GCaMP6s.WPRE.SV40
(#100842-AAV9)

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Brain parenchyma
Prelimbic, SST interneurons
Mouse AAV1 EF1a Control pAAV-Ef1a-DIO EYFP
(#27056-AAV1)

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Brain parenchyma
Around lateral and ventral orbital cortex
Rat AAV8 Syn Chemogenetics pAAV-hSyn-DIO-hM4D(Gi)-mCherry
(#44362-AAV8)

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Brain parenchyma
Prelimbic region of the medial prefrontal cortex; Prelimibic neurons that project to the dorsal raphe nucleus
Rat AAV8 Syn Control pAAV-hSyn-DIO-mCherry
(#50459-AAV8)

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Brain parenchyma
Basal forebrain region. ChAT+ cholinergic neurons and non-cholienrgic neurons (less than 2% among virus expressed cells)
Mouse AAV9 EF1a Optogenetics pAAV-EF1a-double floxed-hChR2(H134R)-EYFP-WPRE-HGHpA
(#20298-AAV9)

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Brain parenchyma
Prelimbic and Infralimibic projection neurons were targeted and labeled with the protein encoded by the virus used
Rat AAV1 CAG Control pAAV.CAG.Flex.Ruby2sm-Flag.WPRE.SV40
(#98928-AAV1)

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Brain parenchyma
Neurons in the prelimbic cortex (pan-neuronal)
Mouse AAV1 Syn Biosensor pGP-AAV-syn-jGCaMP7f-WPRE
(#104488-AAV1)

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Brain parenchyma
Prelimbic cortex, corticothalamic projection neurons
Rat AAV9 EF1a Optogenetics pAAV-Ef1a-DIO hChR2(E123A)-EYFP
(#35507-AAV9)

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Brain parenchyma
Nucleus accumbens, direct pathway medium spiny neurons
Rat AAV8 Syn Chemogenetics pAAV-hSyn-DIO-hM3D(Gq)-mCherry
(#44361-AAV8)

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Brain parenchyma
Indirect pathway medium spiny neurons of the nucleus accumbens
Rat AAV8 Syn Chemogenetics pAAV-hSyn-DIO-hM4D(Gi)-mCherry
(#44362-AAV8)

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Brain parenchyma
Expression was largely localized to the ventral hippocampus. In some cases, expression was also seen in dentate gyrus or entorhinal cortex. Expression was most notable in pyramidal neurons
Mouse AAV1 Syn Biosensor pAAV.Syn.GCaMP6s.WPRE.SV40
(#100843-AAV1)

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Brain parenchyma
Putative CaMKII+ pyramidal cells in CA1 subregion
Mouse AAV9 CaMKIIa Biosensor pENN.AAV.CamKII.GCaMP6f.WPRE.SV40
(#100834-AAV9)

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Brain parenchyma
Although the injection targeted lateral parabrachial nucleus, we observed expression in the adjacent region Kolliker Fuse (KF). We have not confirmed whether these neurons are excitatory or inhibitory
Mouse AAV9 EF1a Optogenetics pAAV-EF1a-double floxed-hChR2(H134R)-mCherry-WPRE-HGHpA
(#20297-AAV9)

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Brain parenchyma
Cerebral cortical neurons
Mouse AAV9 Syn Recombinase pENN.AAV.hSyn.HI.eGFP-Cre.WPRE.SV40
(#105540-AAV9)

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Brain parenchyma
CaMKIIa-positive cells in medial dorsal thalamus
Rat AAV5 CaMKIIa Chemogenetics pAAV-CaMKIIa-hM3D(Gq)-mCherry
(#50476-AAV5)

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Brain parenchyma
Limited expression in noradrenergic cells of the locus coeruleus
Rat AAV5 CAG Biosensor pAAV.CAG.Flex.GCaMP6s.WPRE.SV40
(#100842-AAV5)

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Brain parenchyma
Oxytocinergic neurons in paraventricular hypothalamic nucleus
Mouse AAV5 CAG Biosensor pAAV.CAG.Flex.GCaMP6s.WPRE.SV40
(#100842-AAV5)

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Brain parenchyma
Noradrenergic cells of the locus coeruleus
Rat AAV5 EF1a Control pAAV-Ef1a-DIO EYFP
(#27056-AAV5)

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Brain parenchyma
Basal forebrain Cholinergic neurons and non-cholinergic neurons (less than 2%)
Mouse AAV9 EF1a Control pAAV-Ef1a-DIO EYFP
(#27056-AAV9)

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Brain parenchyma
Based on location and morphology, we felt confident that fluorescent cells in the inferior and superior colliculus were GABAergic, which was the cell class expressing Cre-recombinase in the animal model. In each case where an injection was made, fluorescent cells were present in the injected nucleus
Rat AAV9 EF1a Control AAV-EF1a-BbTagBY
(#45185-AAV9)

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Brain parenchyma
V1 astrocytes
Mouse AAV5 GFAP Biosensor pZac2.1 gfaABC1D-cyto-GCaMP6f
(#52925-AAV5)

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Brain parenchyma
Neurons at injection site (GPe neurons), neurons in neighboring regions (GPi, likely due to spread of virus), and expression of GFP along axons and terminals originating form GPe cells (anterograde transport)
Rhesus macaque AAV5 Syn Optogenetics pAAV-hsyn-Jaws-KGC-GFP-ER2
(#65014-AAV5)

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Brain parenchyma
Only principal neurons axons and cell bodies
Mouse AAV9 CaMKIIa Optogenetics pAAV-CaMKIIa-hChR2(H134R)-EYFP
(#26969-AAV9)

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Brain parenchyma
All cells in the ventral hippocampus
Mouse AAV1 Syn Recombinase AAV pmSyn1-EBFP-Cre
(#51507-AAV1)

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Brain parenchyma
Cortical astrocytes
Mouse AAV5 GFAP Biosensor pZac2.1 gfaABC1D-lck-GCaMP6f
(#52924-AAV5)

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Brain parenchyma
Very limited expression in noradrenergic cells of locus coeruleus
Rat AAV9 CAG Biosensor pAAV.CAG.Flex.GCaMP6s.WPRE.SV40
(#100842-AAV9)

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Brain parenchyma
Neurons within the injection site as well as pyramidal cells throughout the prefrontal cortex
Mouse AAV Retrograde CAG Control pAAV-CAG-tdTomato (codon diversified)
(#59462-AAVrg)

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Brain parenchyma
The expression thus was only observed in the PV interneurons of APC L3
Mouse AAV5 Syn Chemogenetics pAAV-hSyn-DIO-hM3D(Gq)-mCherry
(#44361-AAV5)

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Brain parenchyma
Basolateral amygdala projection neurons
Mouse AAV5 Syn Optogenetics pAAV-Syn-ChrimsonR-tdT
(#59171-AAV5)

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Brain parenchyma
Ubiquitous, as expected
Rat AAV8 Syn Chemogenetics pAAV-hSyn-hM4D(Gi)-mCherry
(#50475-AAV8)

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Brain parenchyma
Ubiquitous, as expected
Rat AAV8 Syn Chemogenetics pAAV-hSyn-hM4D(Gi)-mCherry
(#50475-AAV8)

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Brain parenchyma
We observed expression in all brain regions tested and the cell type was given by the expression of Cre
Mouse AAV8 Syn Chemogenetics pAAV-hSyn-DIO-hM3D(Gq)-mCherry
(#44361-AAV8)

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