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AAV pCAG-FLEX-EGFP-WPRE in Mouse (AAV1)

Addgene #51502-AAV1

Data Submitted By
Kyle Jenks and Jason Shepherd
Submission Date
January 02, 2020
Publication Date
January 02, 2020 (modified May 16, 2023)
Abstract
Not provided
Caption: Z-stack taken in vivo 58 um max projection of layer 2/3 neurons.

Any further use of this image requires permission from the lab who submitted the data.

Vectors Used
AAV pCAG-FLEX-EGFP-WPRE
Addgene #51502-AAV1
pENN.AAV.CamKII 0.4.Cre.SV40
Addgene #105558-AAV1

Virus & Injection

Virus 1

Virus Name
AAV pCAG-FLEX-EGFP-WPRE
Serotype
AAV1
Source
Addgene
Catalog Number
51502-AAV1
Promoter
CAG
Cargo Type
Control
Injection Titer / Dose
1.00E+13 GC/mL
Injection Volume
two 100 nL injections (200 nL total)
Injection Rate
36.8 nL/min
Injector Material
Not provided
Injection Site / Route
Visual cortex, NeuroNames ID: 2102
Additional Details
Binocular Visual Cortex.
View in Addgene Catalog

Virus 2

Virus Name
pENN.AAV.CamKII 0.4.Cre.SV40
Serotype
AAV1
Source
Addgene
Catalog Number
105558-AAV1
Promoter
CaMKII
Injection Titer / Dose
1.00E+13 GC/mL
Injection Volume
100 nL
Injection Rate
36.8 nL/min
Injector Material
Not provided
Injection Site / Route
Cerebral cortex, NeuroNames ID: 39
Additional Details
Excitatory cell types, same surgery; Forebrain: Cerebral cortex (neocortex)
View in Addgene Catalog

Other Details

Species
Mouse
Strain or Cell Line
C57BL/6J
Source
Not provided
Age at Injection
P49
Time After Injection
2 weeks
Detection Method
Direct fluorescence
Assay & Results
Spiny projection neurons successfully labeled. Poor visibility in immediate injection site when using in vivo two-photon imaging. Binocular Visual Cortex, did not confirm cell identity by secondary staining.
Tips & Comments
Less/diluted Cre could have been used.